Overview of Innate and Adaptive/Acquired immunity |
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The Innate Immune System ...
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| ... recognizes both microorganisms and endogenous (host-derived) ligands, and it triggers clearance and/or killing of microorganisms - without or with help from the adaptive immune system. It also triggers apoptotic and cell-death pathways that depend on inflammatory mediators. |
... uses for recognition Pattern Recognition Receptors (PRR), including Toll-Like Receptors (TLR) and Nucleotide-binding Oligomerization Domain (NOD) receptors. This may trigger both infectious and sterile inflammation.
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