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Selected IIR references (for other abstracts, see Lists of IIR Publications):

Bendtzen et al. Human pI 7 interleukin 1 is cytotoxic for pancreatic islets of Langerhans. Science 1986; 232: 1545-1547.

Mandrup-Poulsen et al. Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic b-cell cytotoxicity. J Immunol 1987;139:4077-82.

Bendtzen K. Immune hormones (cytokines); pathogenic role in autoimmune rheumatic diseases and endocrine diseases. Autoimmunity 1989; 2: 177-189.

Eizirik et al. An interleukin-1 receptor antagonist protein protects insulin-producing b cells against suppressive effects of interleukin-1b. Diabetologia 1991;34:445-8.

Welsh et al. Influence of protease on inhibitory and stimulatory effects of interleukin 1b on b-cell function. Diabetes 1991;40:290-4.

Brynskov et al. Cytokines (immunoinflammatory hormones) and their natural regulation in inflammatory bowel diseases (Crohn's disease and ulcerative colitis). A review. Dig Dis 1994; 12:290-304.

Welsh et al. Expression of an insulin/interleukin-1 receptor antagonist hybrid gene in insulin-producing cell lines (HIT-T15 and NIT-1) confers resistance against interleukin-1-induced nitric oxide production. J Clin Invest 1995; 95:1717-1722.

Kayser et al. Immunocytochemical localisation of tumor necrosis factor a in thyroid tissues from patients with neoplastic or autoimmune thyroid disorders. Autoimmunity 1996; 23:91-97.

Nielsen et al. Inhibition of PTH Secretion by Interleukin-1beta in Bovine Parathyroid Glands in Vitro Is Associated with an Up-Regulation of the Calcium- Sensing Receptor mRNA. Biochem Biophys Res Commun 1997; 238:880-885.

Zaccone et al. Interleukin-13 prevents autoimmune diabetes in NOD mice. Diabetes 1999;48:1522-8.

Bovin LF, Bendtzen K. Apoptosis - Programmed cell death (review in Danish). Ugeskr Læg 1999;161:5778-82.

Papaccio et al. Prevention of spontaneous autoimmune diabetes in NOD mice by transferring in vitro antigen-pulsed syngeneic dendritic cells. Endocrinology 2000;141(4):1500-5.

Saldeen et al. Liposome-mediated transfer of IL-1 receptor antagonist gene to dispersed islet cells does not prevent recurrence of disease in syngeneically transplanted NOD mice. Cytokine 2000;12:405-8.

Papaccio et al. An imidazoline compound completely counteracts interleukin-1b toxic effects to rat pancreatic islet b cells. Mol Med 2002;8:536-45.

Li et al. Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6. Clin Immunol 2002;102:135-7.

Nicoletti et al. Serum levels of the interferon-g-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed type 1 diabetes mellitus patients and subjects at risk of developing the disease. Diabetologia 2002; 45: 1107-10.

Di Marco et al. Curative effects of sodium fusidate on the development dinitrobenzene-sulfonic acid (DNB)-induced colitis in rats. Clin Immunol 2003;109:266-71

Nicoletti et al. Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin. Prevention of hyperglycemia and insulitis by a recombinant IL-18-binding protein: Fc construct. Eur J Immunol 2003;33:2278-86.

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