3 Th0, Th1, Th2, Th1/Th2, CD40, CD154, ICAM, LFA-1, CD86, CD28, CD80, CD152, IL-4, IL-10, IL-12, IL-18, DC1, DC2, Dendritic cells, IFN-gamma, Lymphotoxin, IL-2, GM-CSF, IL-3, IL-5, IL-6, IL-9, IL-10, IL-13, humoral, cell-mediated

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At least four forms of T-helper-cells (Th) may be distinguished on the basis of their cytokine repertoire: Th0, Th1, Th2, Th3
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Th0 cells are considered precursors of other Th cells and may produce a mixed spectrum of cytokines. Th1-cells primarily produce interferon gamma (IFN-gamma), interleukin (IL)-2, lymphotoxin (LT)a and granulocyte-macrophage colony-stimulating factor (GM-CSF); they are particularly important in cell-mediated immune reactions. Th2-cells primarily produce IL-3, -4, -5, -6, -10 and -13; they are particularly important in antibody-mediated immune reactions. Th3-cells primarily produces TGF-beta; they are particularly important as Tregulatory cells (Tr) with mostly suppressor functions in many immune reactions. Dendritic cells (DC), specialized in presentation of antigen to Th, appear to decide whether Th1- or Th2-type cells are activated. Hence, DC1 secrete IL-12, which differentiate Th0 to Th1, and DC2, perhaps through production of an unknown cytokine (which is not IL-4), favors differentiation to Th2 cells.